AIDS shattered the confidence of a medical system that believed it had long ago conquered infectious diseases with antibiotics and vaccines. Nonetheless, with unprecedented speed and unprecedented productivity, the scientific community – withstanding almost unbearable pressures – pulled together, and eventually beat back this uninvited guest. In our film, storytellers who were on the front line of research share the tragic emergence of the disease and the enormous pressure to find a treatment. We follow the science and the tireless innovation behind what it took to develop the powerful antiretroviral therapies that have changed AIDS from a death sentence to a manageable chronic disease. This film paints a portrait of the global community – including scientists, activists, clinicians, and many others working together at academic, government, and biopharmaceutical industry laboratories around the world – that had to work together in this race against time.